I have an anecdote!

All games politely offer the ability to invert the y axis. All games except  Myst V: End of Ages. I was working a lot at getting better at Battlefield 2 multiplayer at the time and I always played with the y-axis properly inverted in the way of all higher intelligences. No worries, I thought, Myst is a slow game, I'll just work it out patiently and go back to normal in BF2. But once you fiddle with that sort of thing, something breaks, right there in your mind, and it cannot be undone. I was stuck in limbo where neither scheme worked. I decided to commit to the non-inverted mouse and spent weeks dying looking up at the clouds or down at my shoelaces at the most inappropriate times.